Fat shots, also known as fat-dissolving or fat-burning injections, are gaining popularity as a non-surgical way to target stubborn fat deposits. With new research and advanced products emerging in 2025, understanding the options, benefits, and risks is essential for anyone considering these treatments.
What Are Fat Shots?
Fat shots refer to injectable treatments designed to reduce localized fat deposits or support overall fat loss. There are two main categories:
- Fat-dissolving injections: Target and destroy fat cells in specific areas.
- Fat-burning or weight loss injections: Affect appetite, metabolism, or fat breakdown throughout the body.
How Do Fat-Dissolving Injections Work?
Most fat-dissolving injections use deoxycholic acid (DCA), a bile acid that naturally helps digest fat.
When injected into fatty tissue, DCA breaks down fat cell membranes, causing the fat to liquefy and be removed through the lymphatic system.
Common target areas:
- Chin (double chin)
- Abdomen
- Thighs
- Arms
Popular brands: Kybella, DesoFace, DesoBody
Effectiveness and Results
What to Expect
- Visible reduction in targeted fat after 2–4 sessions, spaced about a month apart.
- Results typically appear after 8 weeks, as the body gradually eliminates destroyed fat cells.
- Treated fat cells are permanently removed, but new fat can develop if weight is regained.
How Long Do Results Last?
| Treatment Area | Typical Duration of Results | Notes |
|---|---|---|
| Chin/Face | 1 year or longer | Maintenance depends on weight stability |
| Abdomen/Body | Permanent if weight stable | New fat can accumulate if weight is gained |
Fat-Burning and Weight Loss Injections
These injections work differently from fat-dissolving shots. Instead of targeting specific fat deposits, they influence the body’s metabolism and appetite.
Examples:
- GLP-1 agonists (like semaglutide, tirzepatide): Suppress appetite, delay gastric emptying, and support weight loss throughout the body.
- Non-stimulant fat burners (e.g., Mitolyn): Support mitochondrial function to enhance fat metabolism without stimulants.
Benefits:
- Average weight loss of 8%–15% over 12–18 months with GLP-1 drugs.
- Improved blood sugar, reduced hunger, and support for diet adherence.
Fat Shots vs. Weight Loss Injections
| Feature | Fat-Dissolving Injections | Weight Loss Injections |
|---|---|---|
| Target | Localized fat pockets | Whole-body fat/metabolism |
| Main Ingredient | Deoxycholic acid (DCA) | GLP-1 agonists, metabolic boosters |
| Results | Spot reduction | Overall weight loss |
| Duration | Permanent (if weight stable) | Ongoing use required for maintenance |
| Common Brands | Kybella, DesoFace, DesoBody | Wegovy, Mounjaro, Mitolyn |
Safety and Side Effects
Fat-Dissolving Injections
Common side effects:
- Swelling, redness, and tenderness (3–5 days)
- Bruising
- Mild pain
Rare but serious risks:
- Infection
- Nerve injury (rare, especially in facial areas)
- Skin necrosis
- Asymmetry or lumps
Weight Loss Injections
Common side effects:
- Nausea, bloating, diarrhea, constipation
- Headache
Precautions:
- Not suitable for everyone (e.g., certain medical conditions)
- Should be administered and monitored by healthcare professionals
Who Is a Good Candidate?
- Fat-dissolving injections: Best for healthy adults with small to moderate fat pockets resistant to diet and exercise.
- Weight loss injections: Suitable for those with obesity or weight-related health issues, as prescribed by a physician.
Not recommended for:
- Individuals with significant skin laxity (may need surgery)
- Pregnant or breastfeeding women
- Those with certain health conditions (consult a doctor)
What to Expect During Treatment
- Consultation: Assessment of goals, medical history, and suitability.
- Procedure: In-office injections, usually taking 20–40 minutes.
- Recovery: Mild swelling and tenderness for a few days; normal activities can often resume quickly.
- Follow-up: Multiple sessions may be needed for optimal results.
Pros and Cons at a Glance
| Pros | Cons |
|---|---|
| Minimally invasive | Temporary swelling and discomfort |
| No general anesthesia or surgery | Possible need for multiple sessions |
| Permanent removal of treated fat cells | Risk of side effects or complications |
| Quick recovery | Not a substitute for weight loss |
Key Takeaways
- Fat shots offer a non-surgical option for reducing stubborn fat or supporting weight loss.
- Fat-dissolving injections are best for targeted areas, while weight loss injections work systemically.
- Results depend on individual factors like age, metabolism, and lifestyle.
- Always consult a qualified healthcare provider to determine the best and safest option for your needs.
Sources
- Inside Aesthetics: Fat Dissolving Injections – Benefits, Risks, and Results
https://www.insideaesthetics.com/fat-dissolving-injections-benefits-risks-results/ - The Skin and Wellbeing Clinic: How Long Do Fat Dissolving Injections Take to Work and How Long Do They Last?
https://www.skinandwellbeingclinic.com/how-long-do-fat-dissolving-injections-take-to-work-and-how-long-do-they-last/ - The Independent Pharmacy: Fat Dissolving Injections vs Weight Loss Injections
https://www.theindependentpharmacy.co.uk/weight-loss-advice/fat-dissolving-injections-vs-weight-loss-injections - Medical News Today: What to Know About Weight Loss Injections
https://www.medicalnewstoday.com/articles/weight-loss-injections - PMC: Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884727/ - PMC: The Effect of Diluted Deoxycholic Acid on Arm Fat Reduction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181182/ - WebMD: Fat-Busting Injections Under Scrutiny
https://www.webmd.com/beauty/news/20040413/fat-busting-injections-under-scrutiny - GoodRx: The Latest Updates on New Weight Loss Drugs
https://www.goodrx.com/well-being/diet-nutrition/new-weight-loss-drugs - GlobeNewswire: Mitolyn Reviews 2025 – Non-Stimulant Weight Loss Supplement
https://www.globenewswire.com/en/news-release/2025/01/15/2809301/0/en/Mitolyn-Reviews-2025-Does-Non-Stimulant-Weight-Loss-Supplement-Work.html
